Histone acetyltransferase KAT5
Kat5 is also known as HTATIP and Tip60. It belongs to the MYST family of histone acetyltransferases. It has been shown that Tip60 is upregulated in the prescence of a Salmonella protein Ssef, which further facilitates the efficient replication of the pathogen inside the macrophages (PMID: 20796290).Tip60 is found to be downregulated in gastric cancers (PMID: 21273583). Tip60 is recruited by E2F family transcription factors leading to promoter acetylation of E2F responsive genes, hence affecting cell cycle progression (PMID: 15121871). It also plays a significant role in cellular apoptosis, DNA damage response and maintainance of genome stability (PMID: 16698308). Human papillomavirus is known to destabilise Tip60 and thereby derepress its own promoters leading to inhibition of apoptotic pathways, cell proliferation and survival (PMID: 20542002). Tip60 is overexpressed in cisplatin resistant cancer cells (PMID: 18458078).
| UniprotKB Accession | Q92993 | ||
|---|---|---|---|
| Alternative Name(s) | 60 kDa Tat-interactive protein (Tip60), Histone acetyltransferase HTATIP (HIV-1 Tat interactive protein), Lysine acetyltransferase 5, cPLA(2)-interacting protein | ||
| Writer for PTM/s | H4K5ac, H4K8ac, H4K12ac, H2AK5ac | ||
| EC number | 2.3.1.48 | ||
| No. of coding genes | Histone acetyltransferase KAT5 is coded by following 1 non-allelic gene/s | ||
| Gene name | K(lysine) acetyltransferase 5 | ||
| Gene symbol | KAT5 | ||
| Promoter region (-700 TSS +300) | Get sequence | ||
| Previous Symbol/s | HTATIP | ||
| Aliases | TIP60, PLIP, cPLA2, HTATIP1, ESA1 | ||
| GeneID | 10524 | ||
| Chromosomal location | 11q13 | ||
| HGNC | 5275 | ||
| Unigene | Hs.397010 | ||
| MIM | 601409 | ||
| RefSeq mRNA | NM_006388.2 | NM_182709.1 | NM_182710.1 |
| RefSeq Protein | NP_006379.2 | NP_874368.1 | NP_874369.1 |
| Disease associations | Cancer: Castration-resistant prostate cancer (CRPCa); PMID: 19938016 Cancer: Gastric cancer; PMID: 21273583 Cancer: Colorectal cancer; PMID: 19846935 | ||
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1