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The DSB-induced acetylation of H2AX lysine 5 is required for further ubiquitination and occurs independently of the phosphorylation of H2AX. K5 acetylation-dependent ubiquitination of H2A.X by the TIP60-UBC13 complex causes its release from damaged chromatin and activates DNA damage response (PMID: 17709392).

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H2AK5ac infosheet
Modified variants Histone H2A type 1, Histone H2A type 1-A, Histone H2A type 1-B/E, Histone H2A type 1-C, Histone H2A type 1-D, Histone H2A type 1-H, Histone H2A type 1-J, Histone H2A type 2-A, Histone H2A type 2-B, Histone H2A type 2-C, Histone H2A type 3, Histone H2A.x
Writer/s Histone acetyltransferase KAT5, Histone acetyltransferase type B catalytic subunit
Disease associationsNo disease associations known for H2AK5ac

Sites of lysine acetylation H1K25ac, H2AK5ac, H2AK9ac, H2BK120ac, H2BK12ac, H2BK15ac, H2BK16ac, H2BK20ac, H2BK46ac, H2BK5ac, H3K14ac, H3K18ac, H3K23ac, H3K27ac, H3K36ac, H3K4ac, H3K56ac, H3K9ac, H4K12ac, H4K16ac, H4K5ac, H4K8ac, H4K91ac