H2AK5ac
The DSB-induced acetylation of H2AX lysine 5 is required for further ubiquitination and occurs independently of the phosphorylation of H2AX. K5 acetylation-dependent ubiquitination of H2A.X by the TIP60-UBC13 complex causes its release from damaged chromatin and activates DNA damage response (PMID: 17709392).
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| Modified variants | Histone H2A type 1, Histone H2A type 1-A, Histone H2A type 1-B/E, Histone H2A type 1-C, Histone H2A type 1-D, Histone H2A type 1-H, Histone H2A type 1-J, Histone H2A type 2-A, Histone H2A type 2-B, Histone H2A type 2-C, Histone H2A type 3, Histone H2A.x |
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| Writer/s | Histone acetyltransferase KAT5, Histone acetyltransferase type B catalytic subunit |
| Eraser/s | |
| Disease associations | No disease associations known for H2AK5ac |
Sites of lysine acetylation H1K25ac, H2AK5ac, H2AK9ac, H2BK120ac, H2BK12ac, H2BK15ac, H2BK16ac, H2BK20ac, H2BK46ac, H2BK5ac, H3K14ac, H3K18ac, H3K23ac, H3K27ac, H3K36ac, H3K4ac, H3K56ac, H3K9ac, H4K12ac, H4K16ac, H4K5ac, H4K8ac, H4K91ac