H3K9ac
H3 lysine 9 acetylation near the transcription start site is essentially related to transcriptional activation (PMID: 16544193). H3K9ac is critical for the recruitment of TFIID at the IFN-gamma locus and hence important in eliciting immune response (PMID: 12419248). E2F1 stimulated GCN5 dependent H3K9 acetylation helps in the recruitment of nucleotide excision repair machinery to the sites of DNA damage (PMID: 20972224). H3K9ac is important for transcriptional elongation of MHC II HLA-DRA genes (PMID: 17478518). SIRT6-dependent deacetylation of H3K9 contributes to the propagation of a specialised chromatin state at mammalian telomeres, which in turn is required for proper telomere metabolism and function. It is also required for the stable association of WRN, the factor that is mutated in Werner syndrome (PMID: 18337721). SIRT6 attenuates NF-?B signalling via H3K9 deacetylation at chromatin hence playing a role in organismal life span (PMID: 19135889).
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| Modified variants | Histone H3.1, Histone H3.1t, Histone H3.2, Histone H3.3 |
|---|---|
| Writer/s | Elongator complex protein 3, Histone acetyltransferase KAT2A |
| Eraser/s | NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-6 |
| Disease associations | Cancer: Pituitary adenomas; PMID: 21453398 Cancer: Lung cancer; PMID: 17906200 Metabolic disorder: Fatty liver disease; PMID: 20816089 Neurological disorder: Huntington's disease; PMID: 17403718 |
Sites of lysine acetylation H1K25ac, H2AK5ac, H2AK9ac, H2BK120ac, H2BK12ac, H2BK15ac, H2BK16ac, H2BK20ac, H2BK46ac, H2BK5ac, H3K14ac, H3K18ac, H3K23ac, H3K27ac, H3K36ac, H3K4ac, H3K56ac, H3K9ac, H4K12ac, H4K16ac, H4K5ac, H4K8ac, H4K91ac