H3K14ac
Histone H3K14 acetylation is critical for the recruitment of TFIID at the IFN-gamma locus and hence important for eliciting proper immune response (PMID: 12419248). In mice, acetylation by CLOCK at H3 Lys-14, is thought to initiate chromatin remodelling by inducing a transcription-permissive state (PMID: 16678094).
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| Modified variants | Histone H3.1, Histone H3.1t, Histone H3.2, Histone H3.3 |
|---|---|
| Writer/s | Bifunctional protein NCOAT, Circadian locomoter output cycles protein kaput, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase MYST3 |
| Eraser/s | |
| Disease associations | No disease associations known for H3K14ac |
Sites of lysine acetylation H1K25ac, H2AK5ac, H2AK9ac, H2BK120ac, H2BK12ac, H2BK15ac, H2BK16ac, H2BK20ac, H2BK46ac, H2BK5ac, H3K14ac, H3K18ac, H3K23ac, H3K27ac, H3K36ac, H3K4ac, H3K56ac, H3K9ac, H4K12ac, H4K16ac, H4K5ac, H4K8ac, H4K91ac