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H3K23 acetylation and H3K4 methylation are part of a non-canonical histone signature which is recognised by chromatin regulator tripartite motif-containing 24 (TRIM24) that binds chromatin and oestrogen receptor to activate the oestrogen-dependent genes associated with cellular proliferation and tumour development. Aberrant expression of TRIM24 negatively correlates with survival of breast cancer patients (PMID: 21164480).

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H3K23ac infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Disease associationsNo disease associations known for H3K23ac

Sites of lysine acetylation H1K25ac, H2AK5ac, H2AK9ac, H2BK120ac, H2BK12ac, H2BK15ac, H2BK16ac, H2BK20ac, H2BK46ac, H2BK5ac, H3K14ac, H3K18ac, H3K23ac, H3K27ac, H3K36ac, H3K4ac, H3K56ac, H3K9ac, H4K12ac, H4K16ac, H4K5ac, H4K8ac, H4K91ac