Notice: Undefined variable: row0 in /var/home/coee/public_html/histome/ptm_sp.php on line 49

Studies show a significant correlation between low expression of H3K18ac and better prognosis of patients with oesophageal squamous cell carcinoma (PMID: 18953329). H3K18 acetylation shows a robust peak at the transcription start site (TSS) of active and poised genes (PMID: 18552846).

Download table as Excel
H3K18ac infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s CREB-binding protein, Elongator complex protein 3, Histone acetyltransferase p300
Disease associations
Cancer: Prostate cancer; PMID: 15988529
Cancer: Lung cancer; PMID: 19349354
Cancer: Kidney cancer; PMID: 19349354
Cancer: Brain tumor (glioblastoma); PMID: 20978174
Cancer: Prostate cancer; PMID: 20841388

Sites of lysine acetylation H1K25ac, H2AK5ac, H2AK9ac, H2BK120ac, H2BK12ac, H2BK15ac, H2BK16ac, H2BK20ac, H2BK46ac, H2BK5ac, H3K14ac, H3K18ac, H3K23ac, H3K27ac, H3K36ac, H3K4ac, H3K56ac, H3K9ac, H4K12ac, H4K16ac, H4K5ac, H4K8ac, H4K91ac