H3K27ac
Loss of Polycomb Repressive Complex 2 (PRC2) activity results in a global increase in H3K27 acetylation suggesting that PRC2 repress transcription by preventing the binding of acetyltrasferases to K27 position (PMID: 20385584). H3K27 acetylation shows a robust peak at the transcription start site (TSS) of active and poised genes (PMID: 18552846).
Download table as Excel
| Modified variants | Histone H3.1, Histone H3.2, Histone H3.3 |
|---|---|
| Writer/s | CREB-binding protein, Histone acetyltransferase p300 |
| Eraser/s | |
| Disease associations | No disease associations known for H3K27ac |
Sites of lysine acetylation H1K25ac, H2AK5ac, H2AK9ac, H2BK120ac, H2BK12ac, H2BK15ac, H2BK16ac, H2BK20ac, H2BK46ac, H2BK5ac, H3K14ac, H3K18ac, H3K23ac, H3K27ac, H3K36ac, H3K4ac, H3K56ac, H3K9ac, H4K12ac, H4K16ac, H4K5ac, H4K8ac, H4K91ac