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Loss of Polycomb Repressive Complex 2 (PRC2) activity results in a global increase in H3K27 acetylation suggesting that PRC2 repress transcription by preventing the binding of acetyltrasferases to K27 position (PMID: 20385584). H3K27 acetylation shows a robust peak at the transcription start site (TSS) of active and poised genes (PMID: 18552846).

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H3K27ac infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s CREB-binding protein, Histone acetyltransferase p300
Disease associationsNo disease associations known for H3K27ac

Sites of lysine acetylation H1K25ac, H2AK5ac, H2AK9ac, H2BK120ac, H2BK12ac, H2BK15ac, H2BK16ac, H2BK20ac, H2BK46ac, H2BK5ac, H3K14ac, H3K18ac, H3K23ac, H3K27ac, H3K36ac, H3K4ac, H3K56ac, H3K9ac, H4K12ac, H4K16ac, H4K5ac, H4K8ac, H4K91ac