Histone acetyltransferase p300

p300 along with CBP exhibit histone acetyltransferase activity (PMID: 8945521). It has been shown that the PHD domain of p300 is dispensable for acetyltransferase activity (PMID: 11691934). A viral oncoprotein E1A is shown to inhibit the histone acetyltrasferase activity of p300/CBP (PMID: 10025405). Acetylation of different lysine residues of histone H3 and H4 by CBP/p300 at the site of double stranded DNA breaks generated during IR radiation have been shown to recruite SWI/SNF chromatin remodellers for DNA repair. Hence, inhibition of CBP activity can help is sensitising cancer cells to radiotherapy or chemotherapy (PMID: 21217779).

Download table as Excel
Histone acetyltransferase p300 (p300 HAT) infosheet
UniprotKB AccessionQ09472
Alternative Name(s)E1A-associated protein p300
Writer for PTM/s H3K27ac, H3K56ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac, H3K18ac
EC number
No. of coding genesHistone acetyltransferase p300 is coded by following 1 non-allelic gene/s
Gene nameE1A binding protein p300
Gene symbolEP300
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
Aliasesp300, KAT3B
Chromosomal location22q13.2
RefSeq mRNANM_001429.3
RefSeq ProteinNP_001420.2
Disease associations
Cancer: Leukemia; PMID: 10700188
Cancer: Breast cancer; PMID: 10700188
Cancer: Pancreatic carcinoma; PMID: 10700188
Cancer: Colorectal cancer; PMID: 10700188
Cancer: Colorectal cancer; PMID: 8622873
Cancer: Gastric cancer; PMID: 8622873
Cancer: Cervical cancer; PMID: 11181085
Developmental disorder: RTS (Rubinstein- Taybi syndrome); PMID: 15706485

Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1