Histone acetyltransferase KAT2B
PCAF majorly catalyse the acetylation of histone H3 and H4. Activated protein C (APC) is shown to regulate PCAF (p300/CBP-associated factor) in human macrophage cells and also changes the acetylation and deacetylation patterns of the genome (PMID: 20976180). PCAF is also known to acetylate non-histone proteins like p53 leading to its activation which in turn is inhibited by MDM2 (PMID: 12068014). PCAF knockdown leads to cell cycle arrest in G1 phase and apoptosis. PCAF is shown to be overexpressed in cisplatin resistant human cancer cells (PMID: 20530585).
| UniprotKB Accession | Q92831 |
|---|---|
| Alternative Name(s) | Histone acetyltransferase PCAF (Histone acetylase PCAF), Lysine acetyltransferase 2B, P300/CBP-associated factor (P/CAF) |
| Writer for PTM/s | |
| EC number | 2.3.1.48 |
| No. of coding genes | Histone acetyltransferase KAT2B is coded by following 1 non-allelic gene/s |
| Gene name | K(lysine) acetyltransferase 2B |
| Gene symbol | KAT2B |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | PCAF |
| Aliases | P/CAF, GCN5, GCN5L |
| GeneID | 8850 |
| Chromosomal location | 3p24 |
| HGNC | 8638 |
| Unigene | Hs.533055 |
| MIM | 602303 |
| RefSeq mRNA | NM_003884.4 |
| RefSeq Protein | NP_003875.3 |
| Disease associations | Cardiac disorders: Coronary heart disease (CHD); PMID: 21062767 Cancer: Esophageal squamous cell carcinoma (ESCC); PMID: 19525977 |
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1