Bifunctional protein NCOAT
Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT) is a bifunctional enzyme consisting of glycoside hydrolase and histone acetyltransferase activity (PMID: 16356930). NCOAT has been shown to acetylate free as well as reconstituted nucleosomal histones and hence may mediate activation of gene transcription (PMID: 15485860).
| UniprotKB Accession | O60502 | |
|---|---|---|
| Alternative Name(s) | Meningioma-expressed antigen 5, Nuclear cytoplasmic O-GlcNAcase and acetyltransferase | |
| Writer for PTM/s | H4K8ac, H3K14ac | |
| EC number | 3.2.1.52, 2.3.1.48 | |
| No. of coding genes | Bifunctional protein NCOAT is coded by following 1 non-allelic gene/s | |
| Gene name | meningioma expressed antigen 5 (hyaluronidase) | |
| Gene symbol | MGEA5 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | ||
| Aliases | MEA5, NCOAT, OGA | |
| GeneID | 10724 | |
| Chromosomal location | 10q24.1-q2 | |
| HGNC | 7056 | |
| Unigene | Hs.500842 | |
| MIM | 604039 | |
| RefSeq mRNA | NM_001142434.1 | NM_012215.3 |
| RefSeq Protein | NP_001135906.1 | NP_036347.1 |
| Disease associations | No disease associations known for Bifunctional protein NCOAT | |
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1