Testis-specific chromodomain protein Y 1

It is a histone acetyltransferase expressed exclusively in testis. The cdy gene is present on the Y chromosome. It is supposed to be responsible for the bulk of histone H4 acetylation in spermatids. It is also linked to histone to protamine transition that occurs in sperms (PMID: 12072557). Overexpression of SRC-1 leads to resistance towards cancer therapy (PMID: 19276281).

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Testis-specific chromodomain protein Y 1 infosheet
UniprotKB AccessionQ9Y6F8
Alternative Name(s)
Writer for PTM/s
EC number
No. of coding genesTestis-specific chromodomain protein Y 1 is coded by following 2 non-allelic gene/s
Gene namechromodomain protein, Y-linked, 1Bchromodomain protein, Y-linked, 1
Gene symbolCDY1BCDY1
Promoter region (-700 TSS +300)Get sequenceGet sequence
Previous Symbol/s
Chromosomal locationYq11.223Yq11.22
RefSeq mRNANM_001003894.1NM_001003895.1NM_004680.2NM_170723.1
RefSeq ProteinNP_001003894.1NP_001003895.1NP_004671.1NP_733841.1
Disease associationsNo disease associations known for Testis-specific chromodomain protein Y 1

Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1