Testis-specific chromodomain protein Y 1
It is a histone acetyltransferase expressed exclusively in testis. The cdy gene is present on the Y chromosome. It is supposed to be responsible for the bulk of histone H4 acetylation in spermatids. It is also linked to histone to protamine transition that occurs in sperms (PMID: 12072557). Overexpression of SRC-1 leads to resistance towards cancer therapy (PMID: 19276281).
| UniprotKB Accession | Q9Y6F8 | |||
|---|---|---|---|---|
| Alternative Name(s) | ||||
| Writer for PTM/s | ||||
| EC number | 2.3.1.48 | |||
| No. of coding genes | Testis-specific chromodomain protein Y 1 is coded by following 2 non-allelic gene/s | |||
| Gene name | chromodomain protein, Y-linked, 1B | chromodomain protein, Y-linked, 1 | ||
| Gene symbol | CDY1B | CDY1 | ||
| Promoter region (-700 TSS +300) | Get sequence | Get sequence | ||
| Previous Symbol/s | ||||
| Aliases | CDY1A | |||
| GeneID | 253175 | 9085 | ||
| Chromosomal location | Yq11.223 | Yq11.22 | ||
| HGNC | 23920 | 1809 | ||
| Unigene | Hs.562095 | Hs.159281 | ||
| MIM | 400016 | |||
| RefSeq mRNA | NM_001003894.1 | NM_001003895.1 | NM_004680.2 | NM_170723.1 |
| RefSeq Protein | NP_001003894.1 | NP_001003895.1 | NP_004671.1 | NP_733841.1 |
| Disease associations | No disease associations known for Testis-specific chromodomain protein Y 1 | |||
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1