Elongator complex protein 3
Elp3 belongs to the GNAT family of histone acetyltransferases. Elp3 is a part of the human elongator complex and is found to acetylate histone H3 (PMID: 11818576). Elp3 mediated H3 acetylation plays a crucial role in familial dysautonomia (PMID: 16713582). There is evidence to believe that Elp3 is invovled in transcription and cell cycle regulation via its histone acetylation activity. It might also help in chromatin organisation during the mitotic cycle (PMID: 19779648). Knockdown of Elp3 has been demonsated to impair paternal DNA demethylation (PMID: 20054296).
| UniprotKB Accession | Q9H9T3 |
|---|---|
| Alternative Name(s) | |
| Writer for PTM/s | H3K9ac, H3K18ac |
| EC number | 2.3.1.48 |
| No. of coding genes | Elongator complex protein 3 is coded by following 1 non-allelic gene/s |
| Gene name | elongation protein 3 homolog (S. cerevisiae) |
| Gene symbol | ELP3 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | FLJ10422, KAT9 |
| GeneID | 55140 |
| Chromosomal location | 8p21.1 |
| HGNC | 20696 |
| Unigene | Hs.491336 |
| MIM | 612722 |
| RefSeq mRNA | NM_018091.5 |
| RefSeq Protein | NP_060561.3 |
| Disease associations | Neurological disorder: Familial dysautonomia (FD); PMID: 16713582 Neurological disorder: Amyotrophic lateral sclerosis (ALS); PMID: 18996918 |
Lysine acetyltransferases Bifunctional protein NCOAT, Chromodomain Y-like protein, Circadian locomoter output cycles protein kaput, CREB-binding protein, Elongator complex protein 3, General transcription factor 3C polypeptide 4, Histone acetyltransferase KAT2A, Histone acetyltransferase KAT2B, Histone acetyltransferase KAT5, Histone acetyltransferase MYST2, Histone acetyltransferase MYST3, Histone acetyltransferase MYST4, Histone acetyltransferase p300, Histone acetyltransferase type B catalytic subunit, N-acetyltransferase 10, Nuclear receptor coactivator 1, Nuclear receptor coactivator 3, Probable histone acetyltransferase MYST1, Testis-specific chromodomain protein Y 1