NAD-dependent deacetylase sirtuin-2

SIRT2 belongs to NAD+ dependent Class III of histone deacetylases and mediates the deacetylation of tubulin in vivo (PMID: 12620231). SIRT2 deacetylates H4 at Lysine 16 position during mitosis which is crucial for the condensation of chromatin (PMID: 16648462). H3K56 deacetylation is mediated by SIRT2 (PMID: 20587414).

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NAD-dependent deacetylase sirtuin-2 infosheet
UniprotKB AccessionQ8IXJ6
Alternative Name(s)SIR2-like protein 2
Eraser for PTM/s H4K16ac, H3K56ac
EC number 3.5.1.-
No. of coding genesNAD-dependent deacetylase sirtuin-2 is coded by following 1 non-allelic gene/s
Gene namesirtuin 2
Gene symbolSIRT2
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sSIR2L
Chromosomal location19q13
RefSeq mRNANM_001193286.1NM_030593.2NM_012237.3
RefSeq ProteinNP_001180215.1NP_085096.1NP_036369.2
Disease associations
Cancer: Gliomas; PMID: 12963026

Lysine deacetylases Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 7, Histone deacetylase 8, Histone deacetylase 9, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-6