NAD-dependent deacetylase sirtuin-2
SIRT2 belongs to NAD+ dependent Class III of histone deacetylases and mediates the deacetylation of tubulin in vivo (PMID: 12620231). SIRT2 deacetylates H4 at Lysine 16 position during mitosis which is crucial for the condensation of chromatin (PMID: 16648462). H3K56 deacetylation is mediated by SIRT2 (PMID: 20587414).
| UniprotKB Accession | Q8IXJ6 | ||
|---|---|---|---|
| Alternative Name(s) | SIR2-like protein 2 | ||
| Eraser for PTM/s | H4K16ac, H3K56ac | ||
| EC number | 3.5.1.- | ||
| No. of coding genes | NAD-dependent deacetylase sirtuin-2 is coded by following 1 non-allelic gene/s | ||
| Gene name | sirtuin 2 | ||
| Gene symbol | SIRT2 | ||
| Promoter region (-700 TSS +300) | Get sequence | ||
| Previous Symbol/s | SIR2L | ||
| Aliases | |||
| GeneID | 22933 | ||
| Chromosomal location | 19q13 | ||
| HGNC | 10886 | ||
| Unigene | Hs.466693 | ||
| MIM | 604480 | ||
| RefSeq mRNA | NM_001193286.1 | NM_030593.2 | NM_012237.3 |
| RefSeq Protein | NP_001180215.1 | NP_085096.1 | NP_036369.2 |
| Disease associations | Cancer: Gliomas; PMID: 12963026 | ||
Lysine deacetylases Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 7, Histone deacetylase 8, Histone deacetylase 9, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-6