Histone deacetylase 6
HDAC6 belongs to the Class IIb histone deacetylase group (PMID: 18292778). Disruption of HDAC6 affects the Hsp90 activity in human leukemia cells (PMID: 15937340). It mediates the deacetylation of acetylated tubulin residues inside the cell and controls cell motility (PMID: 12024216, PMID: 12486003). Also plays a role in immune synapse organization and antigen specific acetylation of microtubules (PMID: 15084271). HDAC6 is also important for the formation of aggresomes (PMID: 14675537). Inhibition of HDAC6 causes DNA damage and sensitizes cancer cells towards anti-cancer agents (PMID: 21037108).
| UniprotKB Accession | Q9UBN7 |
|---|---|
| Alternative Name(s) | |
| Eraser for PTM/s | |
| EC number | 3.5.1.98 |
| No. of coding genes | Histone deacetylase 6 is coded by following 1 non-allelic gene/s |
| Gene name | histone deacetylase 6 |
| Gene symbol | HDAC6 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | KIAA0901, JM21, HD6, FLJ16239 |
| GeneID | 10013 |
| Chromosomal location | Xp11.23 |
| HGNC | 14064 |
| Unigene | Hs.6764 |
| MIM | 300272 |
| RefSeq mRNA | NM_006044.2 |
| RefSeq Protein | NP_006035.2 |
| Disease associations | Cancer: Breast cancer; PMID: 15501975 |
Lysine deacetylases Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 7, Histone deacetylase 8, Histone deacetylase 9, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-6