Histone deacetylase 6

HDAC6 belongs to the Class IIb histone deacetylase group (PMID: 18292778). Disruption of HDAC6 affects the Hsp90 activity in human leukemia cells (PMID: 15937340). It mediates the deacetylation of acetylated tubulin residues inside the cell and controls cell motility (PMID: 12024216, PMID: 12486003). Also plays a role in immune synapse organization and antigen specific acetylation of microtubules (PMID: 15084271). HDAC6 is also important for the formation of aggresomes (PMID: 14675537). Inhibition of HDAC6 causes DNA damage and sensitizes cancer cells towards anti-cancer agents (PMID: 21037108).

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Histone deacetylase 6 (HD6) infosheet
UniprotKB AccessionQ9UBN7
Alternative Name(s)
Eraser for PTM/s
EC number
No. of coding genesHistone deacetylase 6 is coded by following 1 non-allelic gene/s
Gene namehistone deacetylase 6
Gene symbolHDAC6
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliasesKIAA0901, JM21, HD6, FLJ16239
Chromosomal locationXp11.23
RefSeq mRNANM_006044.2
RefSeq ProteinNP_006035.2
Disease associations
Cancer: Breast cancer; PMID: 15501975

Lysine deacetylases Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 7, Histone deacetylase 8, Histone deacetylase 9, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-6