Histone deacetylase 2

HDAC2 belongs to the Class I histone deacetylase group (PMID: 18292778). A non redundant function of HDAC2 has been shown in sensitizing cells of pancreatic ductal adenocarcinoma towards the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and thus suggesting therapeutic role (PMID: 20398369). Recent report demonstrates the role of HDAC2 in HIV-associated neurocognitive disorders (HAND) in humans and suggest its therapeutic value (PMID: 21315782). HDAC2 along with HDAC1 are recruited at the double stranded break sites and play an important role in DNA damage repair to promote Nonhomologous end joining(NHEJ)(PMID: 20802485). HDAC2 helps in the regulation of various p53-target genes (PMID: 20190809). HDAC2 is also shown to be an important molecule in memory formation and synapse plasticity by negatively regulating the two phenomena (PMID: 19424149).

Download table as Excel
Histone deacetylase 2 (HD2) infosheet
UniprotKB AccessionQ92769
Alternative Name(s)
Eraser for PTM/s
EC number
No. of coding genesHistone deacetylase 2 is coded by following 1 non-allelic gene/s
Gene namehistone deacetylase 2
Gene symbolHDAC2
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliasesRPD3, YAF1
Chromosomal location6q21
RefSeq mRNANM_001527.3
RefSeq ProteinNP_001518.3
Disease associations
Cancer: Breast cancer; PMID: 17230502

Lysine deacetylases Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 7, Histone deacetylase 8, Histone deacetylase 9, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-6