Histone deacetylase 2
HDAC2 belongs to the Class I histone deacetylase group (PMID: 18292778). A non redundant function of HDAC2 has been shown in sensitizing cells of pancreatic ductal adenocarcinoma towards the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and thus suggesting therapeutic role (PMID: 20398369). Recent report demonstrates the role of HDAC2 in HIV-associated neurocognitive disorders (HAND) in humans and suggest its therapeutic value (PMID: 21315782). HDAC2 along with HDAC1 are recruited at the double stranded break sites and play an important role in DNA damage repair to promote Nonhomologous end joining(NHEJ)(PMID: 20802485). HDAC2 helps in the regulation of various p53-target genes (PMID: 20190809). HDAC2 is also shown to be an important molecule in memory formation and synapse plasticity by negatively regulating the two phenomena (PMID: 19424149).
| UniprotKB Accession | Q92769 |
|---|---|
| Alternative Name(s) | |
| Eraser for PTM/s | |
| EC number | 3.5.1.98 |
| No. of coding genes | Histone deacetylase 2 is coded by following 1 non-allelic gene/s |
| Gene name | histone deacetylase 2 |
| Gene symbol | HDAC2 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | RPD3, YAF1 |
| GeneID | 3066 |
| Chromosomal location | 6q21 |
| HGNC | 4853 |
| Unigene | Hs.3352 |
| MIM | 605164 |
| RefSeq mRNA | NM_001527.3 |
| RefSeq Protein | NP_001518.3 |
| Disease associations | Cancer: Breast cancer; PMID: 17230502 |
Lysine deacetylases Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 7, Histone deacetylase 8, Histone deacetylase 9, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-6