Histone deacetylase 8
HDAC8 belongs to the Class I histone deacetylase (PMID: 18292778). It is shown to be expressed in many human tissues and cancer cell lines and can act as transcriptional repressor via its deacetylase activity (PMID: 10748112). c-AMP dependent protein kinase A mediates inhibition of HDAC8 via phosphorylation which leads to hyperacetylation of H3 and H4 histones (PMID: 14701748). HDAC8 regulates the activity of telomerase enzyme via PKA phosphosylation which further contributes to tumorigenesis (PMID: 16809764).
| UniprotKB Accession | Q9BY41 |
|---|---|
| Alternative Name(s) | |
| Eraser for PTM/s | |
| EC number | 3.5.1.98 |
| No. of coding genes | Histone deacetylase 8 is coded by following 1 non-allelic gene/s |
| Gene name | histone deacetylase 8 |
| Gene symbol | HDAC8 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | HDACL1 |
| Aliases | RPD3 |
| GeneID | 55869 |
| Chromosomal location | Xq13 |
| HGNC | 13315 |
| Unigene | Hs.310536 |
| MIM | 300269 |
| RefSeq mRNA | NM_018486.2 |
| RefSeq Protein | NP_060956.1 |
| Disease associations | No disease associations known for Histone deacetylase 8 |
Lysine deacetylases Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 7, Histone deacetylase 8, Histone deacetylase 9, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-6