Histone deacetylase 1

HDAC1 belongs to the Class I histone deacetylases and is the first protein to show the deacetylase activity (PMID: 8602529, PMID: 18292778). HDAC1 knockout embryos are lethal (PMID: 12032080). Levels of HDAC1 are shown to be elevated in human pancreatic adenocarcinoma tissues and cell lines. Silencing of HDAC1 via RNAi lead to inhibition of proliferation associated with the upregulation of cyclin-dependent kinase(cdk) inhibitors (PMID: 21301206). HDAC1 has been suggested as a biomarker for benign teratomas (PMID: 21124297). HDAC1 along with HDAC2 are recruited at the double stranded break sites and play an important role in DNA damage repair to promote Nonhomologous end joining (NHEJ)(PMID: 20802485).

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Histone deacetylase 1 (HD1) infosheet
UniprotKB AccessionQ13547
Alternative Name(s)
Eraser for PTM/s H3K56ac
EC number
No. of coding genesHistone deacetylase 1 is coded by following 1 non-allelic gene/s
Gene namehistone deacetylase 1
Gene symbolHDAC1
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sRPD3L1
AliasesHD1, GON-10
Chromosomal location1p34
RefSeq mRNANM_004964.2
RefSeq ProteinNP_004955.2
Disease associations
Cancer: Hormone refractory prostate cancer; PMID: 15042618
Cancer: Gastric cancer; PMID: 11749695
Cancer: Breast cancer; PMID: 17230502

Lysine deacetylases Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 7, Histone deacetylase 8, Histone deacetylase 9, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-6