Histone deacetylase 4
HDAC4 belongs to the Class IIa histone deacetylase group (PMID: 18292778). It acts as a transcriptional corepressor (PMID: 10523670). Silencing of HDAC4 in HeLa cells is shown to mediate anti-proliferative effect (PMID: 19622775).
| UniprotKB Accession | P56524 |
|---|---|
| Alternative Name(s) | |
| Eraser for PTM/s | |
| EC number | 3.5.1.98 |
| No. of coding genes | Histone deacetylase 4 is coded by following 1 non-allelic gene/s |
| Gene name | histone deacetylase 4 |
| Gene symbol | HDAC4 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | KIAA0288, HDAC-A, HDACA, HD4, HA6116 |
| GeneID | 9759 |
| Chromosomal location | 2q37.3 |
| HGNC | 14063 |
| Unigene | Hs.20516 |
| MIM | 605314 |
| RefSeq mRNA | NM_006037.3 |
| RefSeq Protein | NP_006028.2 |
| Disease associations | No disease associations known for Histone deacetylase 4 |
Lysine deacetylases Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 7, Histone deacetylase 8, Histone deacetylase 9, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-6