Histone deacetylase 3
HDAC3 belongs to the Class I histone deacetylase group (PMID: 18292778). HDAC3 plays a crucial role in DNA replication and DNA damage control. It is required for the maintenance of the structure and stability of chromatin. Deletion of Hdac3 in liver cells leads to hepatocellular carcinoma (PMID: 21075309). HDAC3 is required for the deacetylation of H3K4 specifically at the centromeric position leading to sister chromatid cohesion (PMID: 18832068). HDAC3 along with p300, causes deacetylation and repression of the c-myc promoter which leads to transcriptional repression and inhibits premature escape of cells from G1 phase (PMID: 18542060). HDAC3 has been shown to be important in the microtubule attachment to the kinetochore (PMID: 18326024).
| UniprotKB Accession | O15379 |
|---|---|
| Alternative Name(s) | |
| Eraser for PTM/s | H3K4ac |
| EC number | 3.5.1.98 |
| No. of coding genes | Histone deacetylase 3 is coded by following 1 non-allelic gene/s |
| Gene name | histone deacetylase 3 |
| Gene symbol | HDAC3 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | RPD3, HD3, RPD3-2 |
| GeneID | 8841 |
| Chromosomal location | 5q31.1-q31 |
| HGNC | 4854 |
| Unigene | Hs.519632 |
| MIM | 605166 |
| RefSeq mRNA | NM_003883.3 |
| RefSeq Protein | NP_003874.2 |
| Disease associations | Cancer: Breast cancer; PMID: 17230502 |
Lysine deacetylases Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 7, Histone deacetylase 8, Histone deacetylase 9, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-6