NAD-dependent deacetylase sirtuin-3, mitochondrial

SIRT3 belongs to NAD+ dependent Class III of histone deacetylases. Some studies suggest that it is located inside mitochondria (PMID: 12374852) whereas some reports demonstrate its H3K56 deacetylation activity inside the nucleus (PMID: 20587414). Hence its localization is debated.

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NAD-dependent deacetylase sirtuin-3, mitochondrial (hSIRT3) infosheet
UniprotKB AccessionQ9NTG7
Alternative Name(s)SIR2-like protein 3
Eraser for PTM/s H3K56ac
EC number 3.5.1.-
No. of coding genesNAD-dependent deacetylase sirtuin-3, mitochondrial is coded by following 1 non-allelic gene/s
Gene namesirtuin 3
Gene symbolSIRT3
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
Chromosomal location11p15.5
RefSeq mRNANM_001017524.2NM_012239.5
RefSeq ProteinNP_001017524.1NP_036371.1
Disease associationsNo disease associations known for NAD-dependent deacetylase sirtuin-3, mitochondrial

Lysine deacetylases Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 7, Histone deacetylase 8, Histone deacetylase 9, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-6