Serine/threonine-protein kinase 4
MST1 belongs to STE Ser/Thr protein kinase family. Mst1, upon cleavage by caspase-3, phosphorylates H3S14 that is uniquely associated with apoptotic chromatin in species ranging from frogs to humans (PMID: 12757711). This H2B-phosphorylation activity causes immobilization of RCC1 and impairment of NF-kB-p65 nuclear transport which is important for rescuing apoptosis, thus providing a hint at the mechanism of initiation of apoptosis (PMID: 19060893). MST1 is also shown to phosphorylate histone H2A.X at serine 139 position during apoptosis (PMID: 20921231).
| UniprotKB Accession | Q13043 |
|---|---|
| Alternative Name(s) | Mammalian STE20-like protein kinase 1 (MST-1), STE20-like kinase MST1, Serine/threonine-protein kinase Krs-2 |
| Writer for PTM/s | H2BS14ph, H2AS139 |
| EC number | 2.7.11.1 |
| No. of coding genes | Serine/threonine-protein kinase 4 is coded by following 1 non-allelic gene/s |
| Gene name | serine/threonine kinase 4 |
| Gene symbol | STK4 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | MST1, KRS2, YSK3 |
| GeneID | 6789 |
| Chromosomal location | 20q11.2-q1 |
| HGNC | 11408 |
| Unigene | Hs.472838 |
| MIM | 604965 |
| RefSeq mRNA | NM_006282.2 |
| RefSeq Protein | NP_006273.1 |
| Disease associations | Cancer: Colorectal cancer; PMID: 17277767 Cancer: Prostate cancer; PMID: 18381433 |
Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2