Serine/threonine-protein kinase PAK 2
PAK2 is a member of STE Ser/Thr protein kinase family. PAK2 is known to phosphorylate H3S10 and is seen migrating from chromosomes to the contraction ring during the progression of mitotic phase (PMID: 12151336). It is reported to phosphorylate and regulate Aurora kinase A during the mitotic phase of the cell cycle (PMID: 16246726).
| UniprotKB Accession | Q13177 |
|---|---|
| Alternative Name(s) | Gamma-PAK, PAK65, S6/H4 kinase, p21-activated kinase 2 (PAK-2), p58 |
| Writer for PTM/s | H3S10ph |
| EC number | 2.7.11.1 |
| No. of coding genes | Serine/threonine-protein kinase PAK 2 is coded by following 1 non-allelic gene/s |
| Gene name | p21 protein (Cdc42/Rac)-activated kinase 2 |
| Gene symbol | PAK2 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | PAK65, PAKgamma |
| GeneID | 5062 |
| Chromosomal location | 3q29 |
| HGNC | 8591 |
| Unigene | Hs.518530 |
| MIM | 605022 |
| RefSeq mRNA | NM_002577.4 |
| RefSeq Protein | NP_002568.2 |
| Disease associations | No disease associations known for Serine/threonine-protein kinase PAK 2 |
Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2