DNA-dependent protein kinase catalytic subunit

It belongs to the PI3/PI4 Kinase family. Specifically phosphorylates H2A.X at the Serine 139 site during double stranded break repairs caused by IR radiations. Also mediates the Non-homologous end joining (PMID: 14627815) (PMID: 15059890). Autophosphorylation of DNAPK regulates the choice of DSB repair by either Homologous recombination (HR) or Non Homologous End Joining (NHEJ) pathways (PMID: 16314509). Oct1 transcription factor is phosphorylated at multiple sites by DNA-PK in order to stabilise it and provide pro-survival signals to the cell after DNA damage (PMID: 17213819). GAPDH performs nitrosylation of DNAPK via protein-protein transfer of the nitrosyl group (PMID: 20972425).

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DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit, DNA-PKcs) infosheet
UniprotKB AccessionP78527
Alternative Name(s)DNPK1, p460
Writer for PTM/s H2AS139ph
EC number
No. of coding genesDNA-dependent protein kinase catalytic subunit is coded by following 1 non-allelic gene/s
Gene nameprotein kinase, DNA-activated, catalytic polypeptide
Gene symbolPRKDC
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sHYRC, HYRC1
AliasesDNPK1, p350, DNAPK, XRCC7, DNA-PKcs
Chromosomal location8q11
RefSeq mRNANM_001081640.1NM_006904.6
RefSeq ProteinNP_001075109.1NP_008835.5
Disease associationsNo disease associations known for DNA-dependent protein kinase catalytic subunit

Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2