Death-associated protein kinase 3

DAPK3 is a pro-apoptotic kinase and belongs to the CAMK Ser/Thr protein kinase family. It is responsible for phosphorylation of H3 Threonine 11, specifically located at the centromeric region (PMID: 12560483). Expression levels of DAPK is reported to be downregulated in lung cancer (PMID: 12912953). Promoter methylation mediated silencing of DAPK gene is observed in many gastrointestinal cancers (PMID: 12087472).

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Death-associated protein kinase 3 (DAP kinase 3) infosheet
UniprotKB AccessionO43293
Alternative Name(s)DAP-like kinase (Dlk), ZIP-kinase
Writer for PTM/s H3T11ph
EC number
No. of coding genesDeath-associated protein kinase 3 is coded by following 1 non-allelic gene/s
Gene namedeath-associated protein kinase 3
Gene symbolDAPK3
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliasesZIP, ZIPK
Chromosomal location19p13.3
RefSeq mRNANM_001348.1
RefSeq ProteinNP_001339.1
Disease associations
Cancer: Lung cancer; PMID: 12912953
Cancer: Gastrointestinal cancers; PMID: 12087472

Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2