Histone deacetylase 1
HDAC1 belongs to the Class I histone deacetylases and is the first protein to show the deacetylase activity (PMID: 8602529, PMID: 18292778). HDAC1 knockout embryos are lethal (PMID: 12032080). Levels of HDAC1 are shown to be elevated in human pancreatic adenocarcinoma tissues and cell lines. Silencing of HDAC1 via RNAi lead to inhibition of proliferation associated with the upregulation of cyclin-dependent kinase(cdk) inhibitors (PMID: 21301206). HDAC1 has been suggested as a biomarker for benign teratomas (PMID: 21124297). HDAC1 along with HDAC2 are recruited at the double stranded break sites and play an important role in DNA damage repair to promote Nonhomologous end joining (NHEJ)(PMID: 20802485).
| UniprotKB Accession | Q13547 |
|---|---|
| Alternative Name(s) | |
| Eraser for PTM/s | H3K56ac |
| EC number | 3.5.1.98 |
| No. of coding genes | Histone deacetylase 1 is coded by following 1 non-allelic gene/s |
| Gene name | histone deacetylase 1 |
| Gene symbol | HDAC1 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | RPD3L1 |
| Aliases | HD1, GON-10 |
| GeneID | 3065 |
| Chromosomal location | 1p34 |
| HGNC | 4852 |
| Unigene | Hs.88556 |
| MIM | 601241 |
| RefSeq mRNA | NM_004964.2 |
| RefSeq Protein | NP_004955.2 |
| Disease associations | Cancer: Hormone refractory prostate cancer; PMID: 15042618 Cancer: Gastric cancer; PMID: 11749695 Cancer: Breast cancer; PMID: 17230502 |
Lysine deacetylases Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 7, Histone deacetylase 8, Histone deacetylase 9, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-6