Mitogen-activated protein kinase kinase kinase MLT
MLTK belongs to the STE Ser/Thr protein kinase family. It is reported to mediate H3S28 phosphorylation in vivo and can be enhanced by ultraviolet B light (UVB) or epidermal growth factor (EGF) that causes MLTK to be present in the nucleus (PMID: 15684425).
| UniprotKB Accession | Q9NYL2 | |
|---|---|---|
| Alternative Name(s) | Human cervical cancer suppressor gene 4 protein (HCCS-4), Leucine zipper- and sterile alpha motif-containing kinase, MLK-like mitogen-activated protein triple kinase, Mixed lineage kinase-related kinase (MLK-related kinase, MRK), Sterile alpha motif- and leucine zipper-containing kinase AZK | |
| Writer for PTM/s | H3S28ph | |
| EC number | 2.7.11.25 | |
| No. of coding genes | Mitogen-activated protein kinase kinase kinase MLT is coded by following 1 non-allelic gene/s | |
| Gene name | ||
| Gene symbol | Unknown | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | ||
| Aliases | ||
| GeneID | 51776 | |
| Chromosomal location | ||
| HGNC | ||
| Unigene | Notice: Undefined offset: 1 in /var/home/coee/public_html/histome/enzyme_sp.php on line 223||
| MIM | 609479 | |
| RefSeq mRNA | NM_016653.2 | NM_133646.2 |
| RefSeq Protein | NP_057737.2 | NP_598407.1 |
| Disease associations | No disease associations known for Mitogen-activated protein kinase kinase kinase MLT | |
Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2