NAD-dependent deacetylase sirtuin-3, mitochondrial
SIRT3 belongs to NAD+ dependent Class III of histone deacetylases. Some studies suggest that it is located inside mitochondria (PMID: 12374852) whereas some reports demonstrate its H3K56 deacetylation activity inside the nucleus (PMID: 20587414). Hence its localization is debated.
| UniprotKB Accession | Q9NTG7 | |
|---|---|---|
| Alternative Name(s) | SIR2-like protein 3 | |
| Eraser for PTM/s | H3K56ac | |
| EC number | 3.5.1.- | |
| No. of coding genes | NAD-dependent deacetylase sirtuin-3, mitochondrial is coded by following 1 non-allelic gene/s | |
| Gene name | sirtuin 3 | |
| Gene symbol | SIRT3 | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | ||
| Aliases | SIR2L3 | |
| GeneID | 23410 | |
| Chromosomal location | 11p15.5 | |
| HGNC | 14931 | |
| Unigene | Hs.716456 | |
| MIM | 604481 | |
| RefSeq mRNA | NM_001017524.2 | NM_012239.5 |
| RefSeq Protein | NP_001017524.1 | NP_036371.1 |
| Disease associations | No disease associations known for NAD-dependent deacetylase sirtuin-3, mitochondrial | |
Lysine deacetylases Histone deacetylase 1, Histone deacetylase 10, Histone deacetylase 11, Histone deacetylase 2, Histone deacetylase 3, Histone deacetylase 4, Histone deacetylase 5, Histone deacetylase 6, Histone deacetylase 7, Histone deacetylase 8, Histone deacetylase 9, NAD-dependent deacetylase sirtuin-1, NAD-dependent deacetylase sirtuin-2, NAD-dependent deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-6