Protein kinase C beta type
PKC beta belongs to AGC Ser/Thr protein kinase family. It is responsible for threonine 6 phosphorylation of histone H3 which prevents LSD1 from demethylation of H3K9 on androgen dependent activation. This is shown to have implication in prostate cancers (PMID: 20228790). Histones have been used as substrates for demonstrating the phosphorylation activity of PKCs (PMID: 8288312, PMID: 1328200).
| UniprotKB Accession | P05771 | |
|---|---|---|
| Alternative Name(s) | ||
| Writer for PTM/s | H3T6ph | |
| EC number | 2.7.11.13 | |
| No. of coding genes | Protein kinase C beta type is coded by following 1 non-allelic gene/s | |
| Gene name | protein kinase C, beta | |
| Gene symbol | PRKCB | |
| Promoter region (-700 TSS +300) | Get sequence | |
| Previous Symbol/s | PRKCB2, PKCB, PRKCB1 | |
| Aliases | ||
| GeneID | 5579 | |
| Chromosomal location | 16p12 | |
| HGNC | 9395 | |
| Unigene | Hs.460355 | |
| MIM | 176970 | |
| RefSeq mRNA | NM_002738.6 | NM_212535.2 |
| RefSeq Protein | NP_002729.2 | NP_997700.1 |
| Disease associations | Cancer: Hepatocellular carcinoma.; PMID: 19949911 Cancer: Prostate cancer; PMID: 20228790 | |
Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2