Ribosomal protein S6 kinase alpha-4

It belongs to the AGC Ser/Thr protein kinase family. It is a mitogen and stress-activated kinase. It plays an important role to acquire environmental cues and mediate epigenetic changes. MSK2 when activated, leads to the phosphorylation of S28 on H3 which is already methylated K27 causing the loss of PRC2 interaction and hence activation of the target genes (PMID: 20864036).

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Ribosomal protein S6 kinase alpha-4 (S6K-alpha-4) infosheet
UniprotKB AccessionO75676
Alternative Name(s)90 kDa ribosomal protein S6 kinase 4, Nuclear mitogen- and stress-activated protein kinase 2, Ribosomal protein kinase B (RSKB)
Writer for PTM/s H3S28ph
EC number
No. of coding genesRibosomal protein S6 kinase alpha-4 is coded by following 1 non-allelic gene/s
Gene nameribosomal protein S6 kinase, 90kDa, polypeptide 4
Gene symbolRPS6KA4
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/s
AliasesRSK-B, MSK2
Chromosomal location11q11-q13
RefSeq mRNANM_003942.2
RefSeq ProteinNP_003933.1
Disease associationsNo disease associations known for Ribosomal protein S6 kinase alpha-4

Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2