Serine/threonine-protein kinase ATR
ATR belongs to PI3/PI4-kinase family. ATR is reported to phosphorylate H2A.X specifically under replication stress conditions so as to keep a check on the replication process (PMID: 11673449).
| UniprotKB Accession | Q13535 |
|---|---|
| Alternative Name(s) | Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1 |
| Writer for PTM/s | H2AS139ph |
| EC number | 2.7.11.1 |
| No. of coding genes | Serine/threonine-protein kinase ATR is coded by following 1 non-allelic gene/s |
| Gene name | ataxia telangiectasia and Rad3 related |
| Gene symbol | ATR |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | FRP1, SCKL, SCKL1, MEC1 |
| GeneID | 545 |
| Chromosomal location | 3q22-q24 |
| HGNC | 882 |
| Unigene | Hs.271791 |
| MIM | 601215 |
| RefSeq mRNA | NM_001184.3 |
| RefSeq Protein | NP_001175.2 |
| Disease associations | No disease associations known for Serine/threonine-protein kinase ATR |
Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2