Serine-protein kinase ATM

ATM is a member of PI3/PI4-kinase family. ATM acts as a sensor for DNA damage and is important for the phosphorylation of H2A.X as part of the DNA damage response (PMID: 11571274). ATM and DNA-PK are both known to mediate the same reaction and hence have a redundant function (PMID: 15059890). A small fraction of the total ATM is always present in the nucleus and is speculated to be bound to the double stranded break site (PMID: 11454856). ATM is heavily implicated in DNA damage response, tumorigenesis, senescence and cell cycle control (PMID: 15829956, PMID: 15149599, PMID: 19996108).

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Serine-protein kinase ATM infosheet
UniprotKB AccessionQ13315
Alternative Name(s)Ataxia telangiectasia mutated (A-T mutated)
Writer for PTM/s H2AS139ph
EC number
No. of coding genesSerine-protein kinase ATM is coded by following 1 non-allelic gene/s
Gene nameataxia telangiectasia mutated
Gene symbolATM
Promoter region (-700 TSS +300)Get sequence
Previous Symbol/sATA, ATDC, ATC, ATD
AliasesTEL1, TELO1
Chromosomal location11q22-q23
RefSeq mRNANM_000051.3
RefSeq ProteinNP_000042.3
Disease associations
Cancer: Breast cancer; PMID: 11505391
Genetic disorder: Ataxia telangiectasia (AT); PMID: 9887333
Cancer: Diffuse large B-cell lymphomas (DLBCLs); PMID: 12149228

Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2