Tyrosine-protein kinase JAK2
JAK2 belongs to Tyr protein kinase family. JAK2 is shown to phosphorylate histone H3 at tyrosine 41 position which has an inhibitory effect on the binding of HP1-alpha leading to loss of repression. Knockdown of JAK2 is shown to repress Imo2 oncogene by increased binding of HP-1 on its promoter in human leukaemia cells providing hints for the process of leukemogenesis. (PMID: 19783980).
| UniprotKB Accession | O60674 |
|---|---|
| Alternative Name(s) | Janus kinase 2 (JAK-2) |
| Writer for PTM/s | H3Y41ph |
| EC number | 2.7.10.2 |
| No. of coding genes | Tyrosine-protein kinase JAK2 is coded by following 1 non-allelic gene/s |
| Gene name | Janus kinase 2 |
| Gene symbol | JAK2 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | JTK10 |
| GeneID | 3717 |
| Chromosomal location | 9p24 |
| HGNC | 6192 |
| Unigene | Hs.656213 |
| MIM | 147796 |
| RefSeq mRNA | NM_004972.3 |
| RefSeq Protein | NP_004963.1 |
| Disease associations | No disease associations known for Tyrosine-protein kinase JAK2 |
Serine/threonine/tyrosine kinases Cyclin-dependent kinase 17, Cyclin-dependent kinase 3, Cyclin-dependent kinase 5, Death-associated protein kinase 3, DNA-dependent protein kinase catalytic subunit, Glycogen synthase kinase-3 beta, Inhibitor of nuclear factor kappa-B kinase subunit alpha, LIM domain kinase 2, Microtubule-associated serine/threonine-protein kinase-like, Mitogen-activated protein kinase kinase kinase 8, Mitogen-activated protein kinase kinase kinase MLT, Mitotic checkpoint serine/threonine-protein kinase BUB1, Protein kinase C beta type, Protein kinase C delta type, Ribosomal protein S6 kinase alpha-4, Ribosomal protein S6 kinase alpha-5, Serine-protein kinase ATM, Serine/threonine-protein kinase 10, Serine/threonine-protein kinase 12, Serine/threonine-protein kinase 4, Serine/threonine-protein kinase ATR, Serine/threonine-protein kinase haspin, Serine/threonine-protein kinase N1, Serine/threonine-protein kinase Nek6, Serine/threonine-protein kinase Nek9, Serine/threonine-protein kinase PAK 2, Serine/threonine-protein kinase tousled-like 1, Tyrosine-protein kinase BAZ1B, Tyrosine-protein kinase JAK2