Lysine-specific demethylase 4B
JMJD2B belongs to the JHDM3 family of demethylases. It catalyses the demethylation of H3K9me3 (PMID: 16603238). Hypoxia-inducible factor (HIF-1?) is known to induce expression of JMJD2B gene and is involved in renal cancers (PMID: 18984585). Estrogen receptor alpha leads to the upregulation of HIF and hence regulates JMJD2B levels in breast cancer cells (PMID: 20682797).
| UniprotKB Accession | O94953 |
|---|---|
| Alternative Name(s) | JmjC domain-containing histone demethylation protein 3B, Jumonji domain-containing protein 2B |
| Eraser for PTM/s | H3K9me3 |
| EC number | 1.14.11.- |
| No. of coding genes | Lysine-specific demethylase 4B is coded by following 1 non-allelic gene/s |
| Gene name | lysine (K)-specific demethylase 4B |
| Gene symbol | KDM4B |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | JMJD2B |
| Aliases | KIAA0876 |
| GeneID | 23030 |
| Chromosomal location | 19p13.3 |
| HGNC | 29136 |
| Unigene | Hs.654816 |
| MIM | 609765 |
| RefSeq mRNA | NM_015015.2 |
| RefSeq Protein | NP_055830.1 |
| Disease associations | Cancer: Prostrate cancer; PMID: 20607829 Cancer: Renal cancer cells; PMID: 18984585 |
Lysine demethylases Histone lysine demethylase PHF8, Lysine-specific demethylase 2A, Lysine-specific demethylase 2B, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B, Lysine-specific demethylase 4A, Lysine-specific demethylase 4B, Lysine-specific demethylase 4C, Lysine-specific demethylase 4D, Lysine-specific demethylase 5A, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C, Lysine-specific demethylase 5D, Lysine-specific demethylase 6A, Lysine-specific demethylase 6B, Lysine-specific demethylase 7, Lysine-specific demethylase 8, Lysine-specific demethylase NO66, Lysine-specific histone demethylase 1A, Lysine-specific histone demethylase 1B