Lysine-specific demethylase 4A
KDM4A belongs to the JHDM3 family of demethylase proteins. JMJD2A is known to catalyse the demethylation of H3K9me3 and H3K36me3 to di- and mono-methylated state but not to the unmethylated state (PMID: 16603238). It associates with retinoblastoma protein (pRb) and regulates E2F target genes, demonstrating its role in oncogenesis (PMID: 15927959). JMJD2A is reported to interact with N-CoR (nuclear receptor corepressor) and regulate the expression of human achaete scute-like homologue 2 (ASCL2/Hash2) gene which is important for fetoplacental development (PMID: 16024779). JMJD2A is expressed in a cell cycle dependent manner and is reported to timely regulate DNA replication by inhibiting the HP1 gamma occupancy on the chromatin (PMID: 21145482).
| UniprotKB Accession | O75164 |
|---|---|
| Alternative Name(s) | JmjC domain-containing histone demethylation protein 3A, Jumonji domain-containing protein 2A |
| Eraser for PTM/s | H3K9me3, H3K36me3 |
| EC number | 1.14.11.- |
| No. of coding genes | Lysine-specific demethylase 4A is coded by following 1 non-allelic gene/s |
| Gene name | lysine (K)-specific demethylase 4A |
| Gene symbol | KDM4A |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | JMJD2, JMJD2A |
| Aliases | KIAA0677, JHDM3A |
| GeneID | 9682 |
| Chromosomal location | 1p34.1 |
| HGNC | 22978 |
| Unigene | Hs.155983 |
| MIM | 609764 |
| RefSeq mRNA | NM_014663.2 |
| RefSeq Protein | NP_055478.2 |
| Disease associations | Cancer: Prostrate cancer; PMID: 20607829 |
Lysine demethylases Histone lysine demethylase PHF8, Lysine-specific demethylase 2A, Lysine-specific demethylase 2B, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B, Lysine-specific demethylase 4A, Lysine-specific demethylase 4B, Lysine-specific demethylase 4C, Lysine-specific demethylase 4D, Lysine-specific demethylase 5A, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C, Lysine-specific demethylase 5D, Lysine-specific demethylase 6A, Lysine-specific demethylase 6B, Lysine-specific demethylase 7, Lysine-specific demethylase 8, Lysine-specific demethylase NO66, Lysine-specific histone demethylase 1A, Lysine-specific histone demethylase 1B