Lysine-specific demethylase 7
KDM7A belongs to the JHDM1 family of demethylase and is specific to dimethylated forms of H3K9 and H3K27 (PMID: 20023638). Demethylation of the promoter and further activation of FGF4 gene by KDM7A is shown to regulate neuronal differentiation (PMID: 20084082). It is involved in the removal of repressive marks and activation of transcription (PMID: 20629981).
| UniprotKB Accession | Q6ZMT4 |
|---|---|
| Alternative Name(s) | JmjC domain-containing histone demethylation protein 1D |
| Eraser for PTM/s | H3K9me2, H3K27me2 |
| EC number | 1.14.11.- |
| No. of coding genes | Lysine-specific demethylase 7 is coded by following 1 non-allelic gene/s |
| Gene name | jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae) |
| Gene symbol | JHDM1D |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | KIAA1718 |
| GeneID | 80853 |
| Chromosomal location | 7q34 |
| HGNC | 22224 |
| Unigene | Hs.308710 |
| MIM | |
| RefSeq mRNA | NM_030647.1 |
| RefSeq Protein | NP_085150.1 |
| Disease associations | No disease associations known for Lysine-specific demethylase 7 |
Lysine demethylases Histone lysine demethylase PHF8, Lysine-specific demethylase 2A, Lysine-specific demethylase 2B, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B, Lysine-specific demethylase 4A, Lysine-specific demethylase 4B, Lysine-specific demethylase 4C, Lysine-specific demethylase 4D, Lysine-specific demethylase 5A, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C, Lysine-specific demethylase 5D, Lysine-specific demethylase 6A, Lysine-specific demethylase 6B, Lysine-specific demethylase 7, Lysine-specific demethylase 8, Lysine-specific demethylase NO66, Lysine-specific histone demethylase 1A, Lysine-specific histone demethylase 1B