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H3K9 dimethylation is one of the prominent marks of transcriptional repression (PMID: 18552846). These marks also harbour the insulin gene, specifically in Hela cells and human bone marrow-derived mesenchymal stem cells and repress it. Whereas Human islet-derived precursor cells that express insulin does not show occupation of such marks at the insulin locus (PMID: 17901401). Demethylation of H3K9me2 has been observed at the Oct4 and Nanog loci during the process of reprogramming (PMID: 17314394).

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H3K9me2 infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, PR domain zinc finger protein 2
Eraser/s Histone lysine demethylase PHF8, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B, Lysine-specific demethylase 4C, Lysine-specific demethylase 4D, Lysine-specific demethylase 7, Lysine-specific histone demethylase 1A, Lysine-specific histone demethylase 1B
Disease associations
Cancer: Prostate cancer; PMID: 19349354
Cancer: Kidney cancer; PMID: 19349354
Neurological disorders: Fragile X syndrome; PMID: 12232854
Cancer: Gastric cancer; PMID: 18850007
Metabolic disorder: Diabetes; PMID: 18776137
Cancer: Acute myeloid leukaemia; PMID: 16861263
Cancer: Hodgkin's Lymphoma; PMID: 15153943
Cancer: Prostate cancer; PMID: 19739128

Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3