H3K9me2
H3K9 dimethylation is one of the prominent marks of transcriptional repression (PMID: 18552846). These marks also harbour the insulin gene, specifically in Hela cells and human bone marrow-derived mesenchymal stem cells and repress it. Whereas Human islet-derived precursor cells that express insulin does not show occupation of such marks at the insulin locus (PMID: 17901401). Demethylation of H3K9me2 has been observed at the Oct4 and Nanog loci during the process of reprogramming (PMID: 17314394).
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| Modified variants | Histone H3.1, Histone H3.2, Histone H3.3 |
|---|---|
| Writer/s | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, PR domain zinc finger protein 2 |
| Eraser/s | Histone lysine demethylase PHF8, Lysine-specific demethylase 3A, Lysine-specific demethylase 3B, Lysine-specific demethylase 4C, Lysine-specific demethylase 4D, Lysine-specific demethylase 7, Lysine-specific histone demethylase 1A, Lysine-specific histone demethylase 1B |
| Disease associations | Cancer: Prostate cancer; PMID: 19349354 Cancer: Kidney cancer; PMID: 19349354 Neurological disorders: Fragile X syndrome; PMID: 12232854 Cancer: Gastric cancer; PMID: 18850007 Metabolic disorder: Diabetes; PMID: 18776137 Cancer: Acute myeloid leukaemia; PMID: 16861263 Cancer: Hodgkin's Lymphoma; PMID: 15153943 Cancer: Prostate cancer; PMID: 19739128 |
Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3