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H4K20 trimethylation has a role in gene silencing and indexing of pericentric heterochromatin (PMID: 15145825). Loss of this mark on a global level in the genome is a hallmark of human cancer (PMID: 15765097).

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H4K20me3 infosheet
Modified variants Histone H4
Writer/s Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Probable histone-lysine N-methyltransferase NSD2
Disease associations
Blood disorder: Beta-thalassemia, Sickle cell disease (SCD); PMID: 20495075
Cancer: All; PMID: 15765097
Neurological disorders: Fragile X syndrome; PMID: 20843831
Neurological disorders: Sotos syndrome; PMID: 20018718

Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3