H3K9me1
H3K9 methylation is linked to transcriptional repression. LSD1 dependent demethylation of H3K9 leads to de-repression of androgen receptor target genes (PMID: 16079795 ). Monomethylated H4K20 and H3K9 act cooperatively to mark distinct regions of silent chromatin within the mammalian epigenome (PMID: 16517599).
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| Modified variants | Histone H3.1, Histone H3.2, Histone H3.3 |
|---|---|
| Writer/s | Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 |
| Eraser/s | Lysine-specific demethylase 3A, Lysine-specific demethylase 3B, Lysine-specific histone demethylase 1A |
| Disease associations | No disease associations known for H3K9me1 |
Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3