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H3K79 is trimethylated by Dot1L. This modification is supposed to have a role that is distinct from mono and dimethylated forms (PMID: 12628190).

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H3K79me3 infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Histone-lysine N-methyltransferase, H3 lysine-79 specific
Disease associationsNo disease associations known for H3K79me3

Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3