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H3K4me3 is important for transcriptional elongation of MHC II HLA-DRA genes (PMID: 17478518). Beta-cat regulates H3K4 methylation and is counteracted directly by APC at Wnt target genes in vivo (PMID: 16510874). H3K4 methylation by MLL is shown to be involved in Hox gene activation (PMID: 12453418). H2B Lys-120 ubiquitination is a prerequisite for histone H3 'Lys-4' methylation (PMID: 16307923). In mice, H3K4me3 marks contribute to the establishment of 'bivalent domains' in embryonic stem cells that maintain the developmentally essential genes in a poised state for activation or repression (PMID: 16630819).

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H3K4me3 infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, SET and MYND domain-containing protein 3
Eraser/s Histone lysine demethylase PHF8, Lysine-specific demethylase 2B, Lysine-specific demethylase 5A, Lysine-specific demethylase 5B, Lysine-specific demethylase 5C, Lysine-specific demethylase 5D, Lysine-specific demethylase NO66
Disease associations
Renal disorders: Chronic glomerular diseases; PMID: 21060806
Neurological disorders: Alzheimer's disease; PMID: 21922516
Vascular disease: Atherosclerosis; PMID: 20035052
Cancer: Gastric cancer; PMID: 18850007
Immunodeficiency disorders: Omenn's Syndrome; PMID: 18033247
Viral infections: Human herpes simplex virus 1 infections; PMID: 16731913

Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3