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H3K36 methylation restricts the PRC2 mediated spread of H3K27 methylation (PMID: 21239496).

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H3K36me3 infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Histone-lysine N-methyltransferase SETD2, Probable histone-lysine N-methyltransferase NSD2
Eraser/s Lysine-specific demethylase 4A, Lysine-specific demethylase NO66
Disease associations
Neurological disorder: Wolf-Hirschhorn syndrome (WHS); PMID: 19483677
Neurological disorders: Sotos syndrome; PMID: 20018718

Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3