H4K20me1
Monomethylated H4K20 and H3K9 act cooperatively to mark distinct regions of silent chromatin within the mammalian epigenome (PMID: 16517599). H4K20 methylation status (mono- or di-) contributes to chromosome behaviour during mitosis and proper cytokinesis (PMID: 15200950).
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| Modified variants | Histone H4 |
|---|---|
| Writer/s | Histone-lysine N-methyltransferase SETD8, Probable histone-lysine N-methyltransferase NSD2 |
| Eraser/s | Histone lysine demethylase PHF8 |
| Disease associations | No disease associations known for H4K20me1 |
Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3