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Monomethylated H4K20 and H3K9 act cooperatively to mark distinct regions of silent chromatin within the mammalian epigenome (PMID: 16517599). H4K20 methylation status (mono- or di-) contributes to chromosome behaviour during mitosis and proper cytokinesis (PMID: 15200950).

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H4K20me1 infosheet
Modified variants Histone H4
Writer/s Histone-lysine N-methyltransferase SETD8, Probable histone-lysine N-methyltransferase NSD2
Eraser/s Histone lysine demethylase PHF8
Disease associationsNo disease associations known for H4K20me1

Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3