H1K25me1
H1.4 K25 (reported as H1K26) methylation is mediated by Ezh2 of the Polycomb repressive complex (PRC2) which is associated with transcriptional repression and might play a role in the formation of chromatin fibre (PMID: 15099518). H1.4K26 is specifically required for the binding of Heterochromatin protein 1 (HP1), whereas simultaneous phosphorylation at S27 blocks HP1 binding (PMID: 16127177).
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| Modified variants | Histone H1.4 |
|---|---|
| Writer/s | Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5 |
| Eraser/s | Lysine-specific demethylase 4D |
| Disease associations | No disease associations known for H1K25me1 |
Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3