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H1.4 K25 (reported as H1K26) methylation is mediated by Ezh2 of the Polycomb repressive complex (PRC2) which is associated with transcriptional repression and might play a role in the formation of chromatin fibre (PMID: 15099518). H1.4K26 is specifically required for the binding of Heterochromatin protein 1 (HP1), whereas simultaneous phosphorylation at S27 blocks HP1 binding (PMID: 16127177).

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H1K25me1 infosheet
Modified variants Histone H1.4
Writer/s Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
Eraser/s Lysine-specific demethylase 4D
Disease associationsNo disease associations known for H1K25me1

Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3