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H3K27me1 signals are shown to be higher at active promoters than silent promoters, particularly downstream of the Transcription Start Site (TSS) (PMID: 17512414). Some reports argue that this site is dynamic since it is distributed throughout the euchromatic regions but is found to be depleted in the region surrounding the TSS (PMID: 17030614).

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H3K27me1 infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5
Disease associationsNo disease associations known for H3K27me1

Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3