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Methylation of histone H3K4 is linked to active transcription (PMID: 15123803, PMID: 11498594). H3K4 methylation by MLL is shown to be involved in the activation of Hox gene cluster (PMID: 12453418).

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H3K4me2 infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Histone-lysine N-methyltransferase NSD3
Eraser/s Lysine-specific demethylase 5A, Lysine-specific demethylase 5D, Lysine-specific histone demethylase 1A
Disease associations
Cancer: Lung cancer; PMID: 17906200
Cancer: Prostate cancer; PMID: 15988529
Cancer: Lung cancer; PMID: 19349354
Cancer: Kidney cancer; PMID: 19349354
Neurological disorders: Fragile X syndrome; PMID: 12232854
Cancer: Colon cancer; PMID: 18632628
Cancer: Prostate cancer; PMID: 20841388

Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3