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H3K27 dimethylation is one of the prominent marks of transcriptional repression (PMID: 18552846).

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H3K27me2 infosheet
Modified variants Histone H3.1, Histone H3.2, Histone H3.3
Writer/s Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase NSD3
Eraser/s Histone lysine demethylase PHF8, Lysine-specific demethylase 6B, Lysine-specific demethylase 7
Disease associations
Cancer: Leukemia; PMID: 18172012

Sites of lysine methylation H1K186me1, H1K25me1, H2BK5me1, H3K27me1, H3K27me2, H3K27me3, H3K36me1, H3K36me2, H3K36me3, H3K4me1, H3K4me2, H3K4me3, H3K79me1, H3K79me2, H3K79me3, H3K9me1, H3K9me2, H3K9me3, H4K20me1, H4K20me2, H4K20me3