Histone-lysine N-methyltransferase EZH1
EZH1 is part of the Polycomb repressor complex and is found to be abundant in non-proliferative cells in contrast to EZH2 . It mediates H3K27 mono and di methylation but in a weak manner compared to EZH2 thus promoting transcriptional repression (PMID: 19026781, PMID: 8921387).
| UniprotKB Accession | Q92800 |
|---|---|
| Alternative Name(s) | Enhancer of zeste homolog 1 |
| Writer for PTM/s | H3K27me1, H3K27me2 |
| EC number | 2.1.1.43 |
| No. of coding genes | Histone-lysine N-methyltransferase EZH1 is coded by following 1 non-allelic gene/s |
| Gene name | enhancer of zeste homolog 1 (Drosophila) |
| Gene symbol | EZH1 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | KIAA0388, KMT6B |
| GeneID | 2145 |
| Chromosomal location | 17q21.1-q2 |
| HGNC | 3526 |
| Unigene | Hs.194669 |
| MIM | 601674 |
| RefSeq mRNA | NM_001991.3 |
| RefSeq Protein | NP_001982.2 |
| Disease associations | No disease associations known for Histone-lysine N-methyltransferase EZH1 |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3