Histone-lysine N-methyltransferase MLL2
It belongs to the MLL family of proteins. MLL2 is the second homolog of the drosophila trithorax gene and its amplification is supposed to be involved in human cancers (PMID: 10637508). NF-kB recruits MLL2 and MLL1 at MMP9 gene promoters to create H3K4me marks (PMID: 19219072).
| UniprotKB Accession | O14686 |
|---|---|
| Alternative Name(s) | ALL1-related protein, Lysine N-methyltransferase 2B (KMT2B), Myeloid/lymphoid or mixed-lineage leukemia protein 2 |
| Writer for PTM/s | |
| EC number | 2.1.1.43 |
| No. of coding genes | Histone-lysine N-methyltransferase MLL2 is coded by following 1 non-allelic gene/s |
| Gene name | myeloid/lymphoid or mixed-lineage leukemia 2 |
| Gene symbol | MLL2 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | TNRC21 |
| Aliases | ALR, MLL4, CAGL114, KMT2D |
| GeneID | 8085 |
| Chromosomal location | 12q12-q13 |
| HGNC | 7133 |
| Unigene | Hs.120228 |
| MIM | 602113 |
| RefSeq mRNA | NM_003482.3 |
| RefSeq Protein | NP_003473.3 |
| Disease associations | Cancer: Glioblastoma; PMID: 10637508 Cancer: Pancreatic carcinoma; PMID: 10637508 |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3