Histone-lysine N-methyltransferase SUV420H2
SUV420H2 catalyses methylation of H4 at Lysine 20 position. It interacts with HP1 protein and contributes towards the heterochromatin formation (PMID: 19486527). Some studies report that it also catalyses the dimethylation of H4 lysine 20 residues using PR-Set7 mediated monomethylated H3K20 as substrates. This dimethylation of H3K20 is essential for proper DNA damage response (PMID: 18296440).
| UniprotKB Accession | Q86Y97 |
|---|---|
| Alternative Name(s) | Lysine N-methyltransferase 5C, Suppressor of variegation 4-20 homolog 2 (Su(var)4-20 homolog 2, Suv4-20h2) |
| Writer for PTM/s | H4K20me2, H4K20me3 |
| EC number | 2.1.1.43 |
| No. of coding genes | Histone-lysine N-methyltransferase SUV420H2 is coded by following 1 non-allelic gene/s |
| Gene name | suppressor of variegation 4-20 homolog 2 (Drosophila) |
| Gene symbol | SUV420H2 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | |
| Aliases | MGC2705, KMT5C |
| GeneID | 84787 |
| Chromosomal location | 19q13.42 |
| HGNC | 28405 |
| Unigene | Hs.590982 |
| MIM | 613198 |
| RefSeq mRNA | NM_032701.3 |
| RefSeq Protein | NP_116090.2 |
| Disease associations | No disease associations known for Histone-lysine N-methyltransferase SUV420H2 |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3