Histone-lysine N-methyltransferase SUV39H1
SUV39H1 is a mammalian homologue of the yeast Su(var)39h protein. Its major function is methylation of H3 lysine 9 which creates an interaction site for HP1 protein which promotes heterochromatin formation (PMID: 11242053). It is reported to methylate nucleosomal histone in promoter region of leukaemia associated PML-RAR fusion protein in order to promote heterochromatinisation and silencing of the target genes (PMID: 16449642). Disruption of its activity in vivo leads to aberrant mitotic division. it is also involved in the regulation of the chromatin structure (PMID: 10949293). SUV39H1 along with SIRT1 is reported to mediate silencing of rDNA locus in response to energy deficient conditions inside the cell, thus playing a crucial role in energy homeostasis (PMID: 18485871).
| UniprotKB Accession | O43463 |
|---|---|
| Alternative Name(s) | Histone H3-K9 methyltransferase 1 (H3-K9-HMTase 1), Position-effect variegation 3-9 homolog, Suppressor of variegation 3-9 homolog 1 (Su(var)3-9 homolog 1) |
| Writer for PTM/s | H3K9me3 |
| EC number | 2.1.1.43 |
| No. of coding genes | Histone-lysine N-methyltransferase SUV39H1 is coded by following 1 non-allelic gene/s |
| Gene name | suppressor of variegation 3-9 homolog 1 (Drosophila) |
| Gene symbol | SUV39H1 |
| Promoter region (-700 TSS +300) | Get sequence |
| Previous Symbol/s | SUV39H |
| Aliases | KMT1A |
| GeneID | 6839 |
| Chromosomal location | Xp11.23 |
| HGNC | 11479 |
| Unigene | Hs.522639 |
| MIM | 300254 |
| RefSeq mRNA | NM_003173.2 |
| RefSeq Protein | NP_003164.1 |
| Disease associations | Cancer: B cell lymphomas; PMID: 11701123 |
Lysine methyltransferases Histone-lysine N-methyltransferase EZH1, Histone-lysine N-methyltransferase EZH2, Histone-lysine N-methyltransferase MLL, Histone-lysine N-methyltransferase MLL2, Histone-lysine N-methyltransferase MLL3, Histone-lysine N-methyltransferase MLL4, Histone-lysine N-methyltransferase MLL5, Histone-lysine N-methyltransferase NSD3, Histone-lysine N-methyltransferase PRDM9, Histone-lysine N-methyltransferase SETD1A, Histone-lysine N-methyltransferase SETD1B, Histone-lysine N-methyltransferase SETD2, Histone-lysine N-methyltransferase SETD7, Histone-lysine N-methyltransferase SETD8, Histone-lysine N-methyltransferase SETDB1, Histone-lysine N-methyltransferase SETDB2, Histone-lysine N-methyltransferase SETMAR, Histone-lysine N-methyltransferase SUV39H1, Histone-lysine N-methyltransferase SUV39H2, Histone-lysine N-methyltransferase SUV420H1, Histone-lysine N-methyltransferase SUV420H2, Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, Histone-lysine N-methyltransferase, H3 lysine-79 specific, Histone-lysine N-methyltransferase, H3 lysine-9 specific 3, Histone-lysine N-methyltransferase, H3 lysine-9 specific 5, N-lysine methyltransferase SMYD2, PR domain zinc finger protein 2, Probable histone-lysine N-methyltransferase ASH1L, Probable histone-lysine N-methyltransferase NSD2, SET and MYND domain-containing protein 3